PASCO COUNTY, Fla. — The state of Florida is set to take on one of the largest pharmacies in the U.S. in court.

The state is trying to prove Walgreens helped fuel Florida’s opioid epidemic.

The trial is set to start in a Pasco County courtroom Monday. 

Most of the defendants in Florida’s lawsuit over the opioid epidemic have settled for more than $870 million, according to the state attorney general.

One remains: Walgreens Co. is not giving up.

Walgreens' drug store chain has more than 9,000 outlets on street corners throughout the country. The Deerfield, Illinois-based company says it will not settle.

“We are prepared for trial,” said Walgreens spokesman Fraser Engerman in an email.

Florida, led by Attorney General Ashley Moody, contends that Walgreens has been an integral part of the opioid epidemic. As examples of excess, Moody said in a statement that one Walgreens outlet sold 2.2 million opioid tablets in the town of Hudson, Florida, which has about 12,000 residents. Other Walgreens locations, according to the state, increased their orders for opioids by 600% in a two-year period.

“It’s time for Walgreens to face accountability for their part in fueling the opioid crisis, and my team is prepared to vigorously try our strong case against them,” Moody said in a statement.

Walgreens denies the state’s allegations.

The opioid epidemic has been linked to more than 500,000 deaths in the U.S. over the past two decades, counting those from prescription painkillers such as OxyContin and generic oxycodone as well as illicit drugs such as heroin and illegally produced fentanyl.

In the same case as Walgreens, Moody said CVS Health Corp. and CVS Pharmacy Inc. will pay the state $484 million. Teva Pharmaceuticals Industries Ltd. agreed to pay $195 million and Allergan PLC more than $134 million.

Florida has previously obtained millions of dollars in opioid settlements involving McKesson Corp., Cardinal Health Inc., Johnson & Johnson Inc. and AmerisourceBergen Corp.

That leaves Walgreens, at the moment, as the sole defendant in Florida’s opioid case.

OxyContin maker Purdue Pharma has a tentative nationwide deal that includes $6 billion in cash from members of the Sackler family who own the company; drugmaker Johnson & Johnson and the distributors AmerisourceBergen, Cardinal Health and McKesson have finalized settlements totaling $26 billion.

In all, settlements, civil and criminal penalties since 2007 have totaled over $45 billion, according to an Associated Press tally.

Information from the Associated Press was used in this report.